EndoClear™ rat recombinant a-Synuclein protein

Alpha-Synuclein is a major component of Lewy bodies in the affected neurons in Parkinson's disease. This protein consists of a conserved degenerative amino-terminal domain and an acidic carboxyl-terminal with higher sequence divergence. α-Synuclein is predominantly expressed in brain, specifically in cerebellum, thalamus, neocortex, hippocampus, and striatum regions. Other tissues express α-Synuclein at very low levels. The physiological role of α-synuclein is not yet well understood. However, the presence of imperfect KTKEGV lipid interacting repeats suggests that it may be involved in synaptic vesicle homeostasis.

*For more stringent applications, EndoClear™Plus offers the lowest endotoxin research grade.

alpha-synuclein protein available in the market.

The sequence (Accession # NP_062042) corresponding to the full-length rat a-synuclein protein plus an affinity tag was expressed in E. coli. The recombinant a-synuclein protein was purified from bacterial lysate using proprietary method, including tag cleavage. The resulting protein contains an additional Gly at the N-term of the a-synuclein sequence. The calculated molecular mass of the recombinant a-synuclein protein is ~14.44 kDa.

Specifications

Downloads