Custom oligonucleotides
Mid & large-scale oligo manufacturing
We specialize in the mid and large-scale manufacturing of high-quality oligonucleotides for research, diagnostics, and therapeutic applications. With over 35 years of experience, we are a trusted partner for research institutions, pharmaceutical and biotech companies worldwide.
Our expertise in scaling up oligonucleotide production
Whether you need milligram, gram, or hundreds of grams quantities, our state-of-the-art
equipment and robust processes guarantee high yield, excellent purity, and consistent quality.
Our expertise spans all scales of manufacturing—small, mid, and large—ensuring that we can
support your needs for early research, diagnostic, preclinical or clinical applications.
We offer tailored solutions that adapt to the unique requirements of each project, providing the
flexibility needed in terms of chemistry, quantity, quality and delivery to meet your specifications and regulatory standards.
Backbone chemistry expertise
With extensive experience dating back to 1985, we offer a broad range of chemistries to synthesize your custom oligonucleotides. Our capabilities include DNA, RNA, 2’-O-Methyl RNA (2’-O-Me-RNA), 2’-Fluoro RNA (2’-F-RNA), and 2’-O-Methoxyethyl RNA (2’-O-MOE-RNA) as building blocks.
Our chemists are highly skilled in working with various backbone linkages, including phosphodiester, phosphorothioate, and methylphosphonate, to enhance the stability, binding affinity, and resistance to degradation of your oligonucleotides.
A wide variety of modifications
Our scientists are not only experts in oligonucleotide backbones but also in modifying and coupling nucleic acid sequences to enhance their functionality and performance.
We specialize in a wide range of chemical modifications, including conjugation with cholesterol, PEG (polyethylene glycol), peptides, and other functional groups to improve stability, cellular uptake, and bioavailability of your molecule.
Flexible format approach
Our large-scale oligonucleotides are delivered in 50 mL vials as the standard format. For added flexibility, aliquots in 20 mL and 10 mL vials are available upon request, allowing us to match your specific workflow requirements.
Whether you need large or smaller precise quantities, our delivery formats are designed to ensure convenience, minimize handling time, and maintain compatibility with your production processes.
Applications across Research, Diagnostics, and Therapeutics
We offer a broad spectrum of oligonucleotide grades to suit the diverse needs of our clients.
Research
Oligonucleotides
Ideal for exploratory research, we offer high performance custom oligonucleotides at a competitive price for applications such as PCR, and next-generation sequencing.
Diagnostic Oligonucleotides
Manufactured under ISO 13485, our Oligos are optimized for use in molecular diagnostics, providing reliable results in pre-diagnostic and diagnostic assays.
Therapeutic Oligonucleotides
Custom-synthesized oligonucleotides, tailored both for pre-clinical and clinical trials, are designed to meet the highest standards of therapeutic development.
Global Presence
We produce large-scale oligonucleotides at our state-of-the-art facilities in Belgium.
Our international reach is supported by dedicated project managers and customer support teams that work closely with you to ensure timely and reliable delivery, regardless of your location.