Adhesion and ECM Assay Kits

Matrix metalloproteinases (MMPs)

MMPs belong to a family of secreted or membrane-associated zinc endopeptidases capable of digesting extracellular matrix components.^1-2

The family currently includes more than 25 members that can be divided into collagenases (MMP-1, -8, and -13), gelatinases (MMP-2 and 9), stromelysins (MMP-3 and 10), matrilysins (MMP-7 and 26), and the membrane-type MMPs (MMP-14 to 17 and 24).

Collectively, MMPs cleave most, if not all, of the constituents of the extracellular matrix (ECM) and are involved in the breakdown and remodeling of many tissues and organs.

They preferentially cleave specific substrate sequences, but most often, one substrate can be cleaved by several MMP members.

AnaSpec is providing a comprehensive list of SensoLyte® assay kits to monitor the activity of MMPs and other adhesion-related proteases.

References

1. Woessner, J. et al. J. Biol. Chem. 263, 16918 (1988)
2. Woessner, J. FASEB J. 5, 2145 (1991)