Beta-Amyloid 1-40

Beta-Amyloid 1-40 - a major component of amyloid plaques

Sequential proteolytic cleavage of the Amyloid Precursor Protein (APP) by secretases (α, b, g) generates beta-Amyloid peptide fragments, of which beta-Amyloid 1-42 forms a major component of amyloid plaques in neurons of Alzheimer’s disease (AD) brains.

beta-Amyloid 1-40 is the other major C-terminal variant of the Amyloid protein and is usually taken as a negative control when studying beta-Amyloid 1-42 effects in AD. Beta-Amyloid 1-40 is the primary soluble species with 10-fold higher secretion than that of beta-Amyloid 42 in normal brains.

Researchers study the deposition of beta-Amyloid 1-40 in AD brains in correlation to synaptic and neuronal loss in relation to biophysical aggregation states; microglial involvement in AD pathogenesis; detection of beta-Amyloid (1-40) and mutant species in CSF (for biomarker discovery) or in lipid vesicles to mimic biologic membranes; evaluate neuroprotective effects of natural and synthetic analogues against beta-Amyloid secretion and aggregation etc.

We offer one of the largest collections of beta-amyloid 1-40 peptides, including native and modified sequences, and specialized formulations, featuring our Aggresure™ and GMP grade (for in vitro use) beta-Amyloid 1-40. In addition, we provide a variety of fluorescently labeled peptides including those labeled with our HiLyte™ Fluor 488, HiLyte™ Fluor 555, and HiLyte™ Fluor 647 dyes.  For your convenience, we also synthesize large single batches of native beta-amyloid 1-40 with high purity.