Custom ASO & siRNA Manufacturing
ScreenToLead™ Oligos
Our ScreenToLead™ Oligos service streamlines your candidate screening process by providing tailored ASO & siRNA oligos with rapid turnaround times.
Predefined oligo packages
for drug discovery
Efficient screening is a key step in early drug development, helping identify the most promising antisense (ASO) or interference (siRNA) oligonucleotide candidates. We offer predefined packages with carefully selected parameters, ensuring oligonucleotides with the right quality standards for efficient high-throughput screening of potential drug candidates.
| Package | Specifications |
|---|---|
| Custom-Modified ASOs Cat# SC-STL-Full |
ScreenToLead™ Oligos - 15–22-mer ASOs with partially to fully modified sequences. |
| Gapmer ASOs Cat# SC-STL-GAP |
ScreenToLead™ Oligos - 15-22-mer Gapmer ASOs with a maximum of 10 modifications. |
| Custom-modified siRNAs Cat# SC-STL-SIRNA |
ScreenToLead™ Oligos - 18-22-mer + 2dT (overhang) siRNAs with partially to fully modified sequence. |
Six reasons to choose
ScreenToLead™ Oligos
Tailored ASO synthesis
Scalable manufacturing of custom ASO and siRNA sequence.
Chemistries & modifications
Offering LNA®, 2'O-Me, 2'O-MOE, 2’-Fluoro RNA, and Phosphorothioate modified backbones, supporting stability, binding affinity, and efficacy.
High-throughput synthesis
Shasta synthesizers enable the simultaneous synthesis of up to 192 oligonucleotides, accelerating candidate screening.
Purification options
SePOP desalting is provided by default, with HPLC purification available on request for projects requiring higher purity.
Quality
controls
Mass spectrometry and single quantification provide oligos with the appropriate quality for effective screening applications.
Delivery
format
Delivered dried in single tubes, ensuring convenient handling and easy integration into your screening workflows.
Ordering specification
Format: Desalted, dried in single tubes.
Optional Purification: HPLC purification available upon request.
Delivery Time: Average turnaround of 2–3 weeks.
- ASO
- Minimum Order: 20 oligos per set
- Minimum delivered qty: 10 nmoles/ASO
- Chemistries & modifications: LNA®, 2’O-Me, 2’O-MOE, 2’Fluoro RNA
Full Phosphorothioate backbone
- siRNA
- Minimum Order: 20 oligos per set
- Minimum delivered qty: 22 nmoles/siRNA duplex
- Chemistries & modifications: 2’O-Me, 2’O-MOE, 2’Fluoro RNA
≤10 Phosphorothioates / strand
How to get started
Prepare Your Sequences: Compile the ASO sequences you wish to synthesize in the Excel file.
Request a Quote: Send your file to receive a personalized quote.
