Insulin B (9-23) - 1 mg
- Cat.Number : AS-61532
- Manufacturer Ref. :
-
Availability :
In stock
This insulin B-chain peptide binds to a class II histocompatibility complex (MHC) allele called I-Ag7. A number of autoimmune diseases has been linked to class II proteins encoded by the MHC. Type 1 diabetes, or insulin-dependent diabetes mellitus, is a T cell-mediated disease that results in autoimmune destruction of pancreatic ß cells leading to hyperglycemia. This insulin B peptide may be a self-antigen candidate that could initiate the disease. Immunization with this peptide in mice led to autoantibodies and insulitis.
Specifications
| Chemistry | |
| Sequence one letter code |
|
|---|---|
| Sequence three letter code |
|
| Molecular Formula |
|
| Molecular Mass/ Weight |
|
| Modification | |
| Conjugation |
|
| Quantity & Purity | |
| Purity |
|
| Storage & stability | |
| Form |
|
| Storage Conditions |
|
| Activity | |
| Biomarker Target | |
| Research Area | |
| Sub-category Research Area | |
| Usage |
|
| Source | |
| Source / Species |
|
| Codes | |
| Code Nacres |
|
Downloads
You may also be interested in the following product(s)
Amylin (1-37), Islet Amyloid Polypeptide, IAPP, human - 1 mg
Citations
Cutting Edge: immunosuppressant as adjuvant for tolerogenic immunization
J Immunol. . 2008 Apr 15 ; 180(8) 5172 | DOI : 10.4049/jimmunol.180.8.5172
- Y. Kang
- et al
Enhanced trafficking to the pancreatic lymph nodes and auto-antigen presentation capacity distinguishes peritoneal B lymphocytes in non-obese diabetic mice.
Diabetologia . 2009 Nov 22 ; 53(2) 346 | DOI : 10.1007/s00125-009-1599-x
- S. Alam
- et al
Inflammatory Tendencies and overproduction of IL-17 in the colon of young NOD mice are counteracted with diet change.
Diabetes . 2010 Jun 14 ; 59(9) 2237 | DOI : 10.2337/db10-0147
- C. Alam
- et al