Insulin B (9-23) - 1 mg
- Cat.Number : AS-61532
- Manufacturer Ref. :
-
Availability :
In stock
This insulin B-chain peptide binds to a class II histocompatibility complex (MHC) allele called I-Ag7. A number of autoimmune diseases has been linked to class II proteins encoded by the MHC. Type 1 diabetes, or insulin-dependent diabetes mellitus, is a T cell-mediated disease that results in autoimmune destruction of pancreatic ß cells leading to hyperglycemia. This insulin B peptide may be a self-antigen candidate that could initiate the disease. Immunization with this peptide in mice led to autoantibodies and insulitis.
Specifications
Chemistry | |
Sequence one letter code |
|
---|---|
Sequence three letter code |
|
Molecular Formula |
|
Molecular Mass/ Weight |
|
Modification | |
Conjugation |
|
Quantity & Purity | |
Purity |
|
Storage & stability | |
Form |
|
Storage Conditions |
|
Activity | |
Biomarker Target | |
Research Area | |
Sub-category Research Area | |
Usage |
|
Source | |
Source / Species |
|
Codes | |
Code Nacres |
|
Downloads
You may also be interested in the following product(s)
![Tube of Amylin (1-37) peptide, human](/assets/cache/81261303-b45a-4505-a86b-cdb2cecb40a9/500x500/as-60804-img-en-as-60804-01.jpg)
Amylin (1-37), Islet Amyloid Polypeptide, IAPP, human - 1 mg
![Tube of Glucagon (1-29) peptide](/assets/cache/695c9408-aa8a-4749-8289-95c16229e0d6/500x500/as-22456-img-en-as-22456-01.jpg)
![Image of a kit SensoLyte 520 IDE Activity Assay Kit Fluorimetric](/assets/cache/e96d74ef-17e4-4666-9b9d-f36aa5011d13/500x500/as-72231-img-en-as-72231-01.jpg)
Citations
Cutting Edge: immunosuppressant as adjuvant for tolerogenic immunization
J Immunol. . 2008 Apr 15 ; 180(8) 5172 | DOI : 10.4049/jimmunol.180.8.5172
- Y. Kang
- et al
Enhanced trafficking to the pancreatic lymph nodes and auto-antigen presentation capacity distinguishes peritoneal B lymphocytes in non-obese diabetic mice.
Diabetologia . 2009 Nov 22 ; 53(2) 346 | DOI : 10.1007/s00125-009-1599-x
- S. Alam
- et al
Inflammatory Tendencies and overproduction of IL-17 in the colon of young NOD mice are counteracted with diet change.
Diabetes . 2010 Jun 14 ; 59(9) 2237 | DOI : 10.2337/db10-0147
- C. Alam
- et al