Amyloid-Forming Peptide GNNQQNY - 1 mg
- Cat.Number : AS-62762
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This is a heptapeptide from the N-terminal prion-determining domain of the yeast protein Sup35 that forms amyloid fibrils. The availability of its detailed atomic oligomeric structure makes it a good model for studying the early stage of aggregation. The GNNQQNY dimer forms three stable sheet structures. in-register parallel, off-register parallel, and anti-parallel. The in-register parallel dimer, which is close to the amyloid beta-sheet structure, has few interpeptide hydrogen bonds, making hydrophobic interactions more important and increasing the conformational entropy compared to the anti-parallel sheet.
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Citations
Structure of the cross-β spine of amyloid-like fibrils.
Nature . 2005 Jun 09 ; 435(7043) 773 | DOI : 10.1038/nature03680
- R. Nelson
- et al