Beta-Amyloid (1-42)

Importance of the Dimethylamino Functionality on a Multifunctional Framework for Regulating Metals, Amyloid-β, and Oxidative Stress in Alzheimer’s Disease

Inorg Chem . 2016 Apr 27 ; 55(10) 5000 | DOI : 10.1021/acs.inorgchem.6b00525

• J. Derrick
• et al

Tailoring the antibody response to aggregated Aß using novel Alzheimer-Vaccines

PLoS One . 2015 Jan 22 ; 10(1) e0115237 | DOI : 10.1371/journal.pone.0115237

• M. Mandler
• et al

LC3 overexpression reduces Aβ neurotoxicity through increasing α7nAchR expression and autophagic activity in neurons and mice

Neuropharmacology . 2015 Feb 14 ; 93 243 | DOI : 10.1016/j.neuropharm.2015.02.003

• SY. Hung
• et al

Toll-Like Receptor 2 and NLRP3 Cooperate To Recognize a Functional Bacterial Amyloid, Curli

Infect Immun. . 2014 Nov 24 ; 83(2) 693 | DOI : 10.1128/IAI.02370-14

• GJ. Rapsinski
• et al

Hypersensitivity of the hippocampal CA3 region to stress-induced neurodegeneration and amyloidogenesis in a rat model of surgical menopause

Brain . 2013 May 01 ; 136(Pt 5) 1432 | DOI : 10.1093/brain/awt046

• QG. Zhang
• et al

Glutamine Acts as a Neuroprotectant against DNA Damage, Beta-Amyloid and H2O2-Induced Stress

PLoS One . 2012 Mar 08 ; 7(3) e33177 | DOI : 10.1371/journal.pone.0033177

• J. Chen
• K. Herrup

A Chemical Analog of Curcumin as an Improved Inhibitor of Amyloid Abeta Oligomerization

PLoS One . 2012 Mar 19 ; 7(3) e31869 | DOI : https://doi.org/10.1371/journal.pone.0031869

• RA. Orlando
• et al

Microglial Amyloid-1-40 Phagocytosis Dysfunction Is Caused by High-Mobility Group Box Protein-1: Implications for the Pathological Progression of Alzheimer’s Disease

Int J Alzheimers Dis . 2012 Feb 24 ; 2012 11 | DOI : http://dx.doi.org/10.1155/2012/685739

• K. Takata
• et al

Amyloid beta dimers/trimers potently induce cofilin-actin rods that are inhibited by maintaining cofilin-phosphorylation

Mol Neurodegener . 2011 Jan 24 ; 6 10 | DOI : 10.1186/1750-1326-6-10

• RC. Davis
• et al

A screening UHPLC–MS/MS method for the analysis of amyloid peptides in cerebrospinal fluid of preclinical species

Bioanalysis . 2010 Dec 23 ; 3(1) 45 | DOI : 10.4155/bio.10.163

Regulation of Matrix Metalloproteinase 2 by Oligomeric Amyloid β Protein

Brain Res . 2011 Mar 02 ; 1387 141 | DOI : 10.1016/j.brainres.2011.02.078

• W. Li
• et al

Syntheses and characterization of novel oxoisoaporphine derivatives as dual inhibitors for cholinesterases and amyloid beta aggregation

Eur J Med Chem . 2011 Mar 01 ; 46(5) 1572 | DOI : 10.1016/j.ejmech.2011.02.005

• YP. Li
• et al

Structural and functional alterations in amyloid-β precursor protein induced by amyloid-β peptides

J Alzheimers Dis . 2014 Apr 28 ; 25(3) 547 | DOI : 10.3233/JAD-2011-101938

• CP. Libeu
• et al

Allosteric modulator desformylflustrabromine relieves the inhibition of α2β2 and α4β2 nicotinic acetylcholine receptors by β-Amyloid 1–42 peptide

J Mol Neurosci . 2011 Mar 22 ; 45(1) 42 | DOI : 10.1007/s12031-011-9509-3

• A. Pandya
• et al

S-Nitrosylation activates Cdk5 and contributes to synaptic spine loss induced by β-amyloid peptide

PNAS . 2011 Aug 23 ; 108(34) 14330 | DOI : https://doi.org/10.1073/pnas.1105172108

• J. Qu
• et al

Lipoxin A4 inhibits the production of proinflammatory cytokines induced by β-amyloid in vitro and in vivo

BBRC . 2011 May 13 ; 408(3) 382 | DOI : https://doi.org/10.1016/j.bbrc.2011.04.013

• J. Wu
• et al

Silibinin: A novel inhibitor of Aβ aggregation

Neurochem Int . 2011 Feb 01 ; 58(3) 399 | DOI : https://doi.org/10.1016/j.neuint.2010.12.017

• F. Yin
• et al

A new tacrine-melatonin hybrid reduces amyloid burden and behavioral deficits in a mouse model of Alzheimer's Disease

Neurotox Res . 2009 Sep 23 ; 17(4) 421 | DOI : 10.1007/s12640-009-9121-2

• C. Spuch
• et al

HIV-1 protein-mediated amyloidogenesis in rat hippocampal cell cultures

Neurosci Lett . 2010 May 21 ; 475(3) 174 | DOI : 10.1016/j.neulet.2010.03.073

• MY. Aksenov
• et al

Higher soluble amyloid β concentration in frontal cortex of young adults than in normal elderly or Alzheimer's Disease

Brain Pathol . 2010 Jun 07 ; 20(4) 787 | DOI : https://doi.org/10.1111/j.1750-3639.2010.00374.x

• Z. Van Helmond
• et al

Prostaglandin E2 reduces amyloid β-induced phagocytosis in cultured rat microglia

Brain Res . 2010 Apr 06 ; 1323 11 | DOI : https://doi.org/10.1016/j.brainres.2010.01.086

• T. Nagano
• et al

CpG-ODNs induces up-regulated expression of chemokine CCL9 in mouse macrophages and microglia

Cellular Immuno . 2010 Jan 01 ; 260(2) 113 | DOI : https://doi.org/10.1016/j.cellimm.2009.10.001

• C. Ravindran
• et al

An improved method for generating consistent soluble amyloid-beta oligomer preparations for in vitro neurotoxicity studies

J Neurosci Methods . 2010 Jul 15 ; 190(2) 171 | DOI : 10.1016/j.jneumeth.2010.05.001

• D. Ryan
• et al

Elevation of β-Amyloid 1-42 Autoantibodies in the Blood of Amnestic Patients With Mild Cognitive Impairment

Arch Neurol . 2010 Jul 01 ; 67(7) 867 | DOI : 10.1001/archneurol.2010.137

• D. Storace
• et al

Increased expression of cholesterol 24S-hydroxylase results in disruption of glial glutamate transporter EAAT2 association with lipid rafts: a potential role in Alzheimer's disease

J Neurochem . 2010 Apr 14 ; 113(4) | DOI : https://doi.org/10.1111/j.1471-4159.2010.06661.x

• G. Tian
• et al

Chronic psychosocial stress accelerates impairment of long-term memory and late-phase long-term potentiation in an at-risk model of Alzheimer's disease

Hippocampus . 2011 Jun 24 ; 21(7) | DOI : https://doi.org/10.1002/hipo.20790

• TT. Tran
• et al

Gelsolin Restores A-Induced Alterations in Choroid Plexus Epithelium

J Biomed and Biotech . 2010 Jan 19 ; 2010 7 | DOI : http://dx.doi.org/10.1155/2010/805405

• T. Vargas
• et al

Two-Photon and Time-Resolved Fluorescence Conformational Studies of Aggregation in Amyloid Peptides

J Phy CehmB . 2010 Apr 29 ; 114 7112 | DOI : https://doi.org/10.1021/jp101496y

• Y. Wang
• et al

Pyroglutamate Abeta pathology in APP/PS1KI mice, sporadic and familial Alzheimer’s disease cases

J Neural Transm . 2010 Jan 01 ; 117(1) 85 | DOI : 10.1007/s00702-009-0314-x

• O. Wirths
• et al

Apoptosis is directly related to intracellular amyloid accumulation in a cell line derived from the cerebral cortex of a trisomy 16 mouse, an animal model of Down syndrome

Neurosci Lett . 2010 Feb 05 ; 470(1) 81 | DOI : https://doi.org/10.1016/j.neulet.2009.12.062

• C. Arriagada
• et al

Mutant presenilin 1 increases the expression and activity of BACE1

JBC . 2009 Feb 05 ; 284 9027 | DOI : 10.1074/jbc.M805685200

• L. Giliberto
• et al

β-Amyloid Impairs AMPA Receptor Trafficking and Function by Reducing Ca2+/Calmodulin-dependent Protein Kinase II Synaptic Distribution

JBC . 2009 Feb 24 ; 284 10639 | DOI : 10.1074/jbc.M806508200

• Z. Gu
• et al

Amyloid-dependent triosphosphate isomerase nitrotyrosination induces glycation and tau fibrillation

Brain . 2009 Feb 27 ; 132(5) 1335 | DOI : https://doi.org/10.1093/brain/awp023

• FX. Guix
• et al

Amyloid β Interaction with Receptor for Advanced Glycation End Products Up-Regulates Brain Endothelial CCR5 Expression and Promotes T Cells Crossing the Blood-Brain Barrier

J Immunol . 2009 May 01 ; 182(9) 5778 | DOI : https://doi.org/10.4049/jimmunol.0803013

• M. Li
• et al

Macrophage-Mediated Degradation of β-Amyloid via an Apolipoprotein E Isoform-Dependent Mechanism

J Neurosci . 2009 Mar 18 ; 29(11) 3603 | DOI : https://doi.org/10.1523/JNEUROSCI.5302-08.2009

• L. Zhao
• et al

Inflammatory Response in the Hippocampus of PS1M146L/APP751SL Mouse Model of Alzheimer's Disease: Age-Dependent Switch in the Microglial Phenotype from Alternative to Classic

J Neurosci . 2008 Nov 05 ; 28(45) 11650 | DOI : https://doi.org/10.1523/JNEUROSCI.3024-08.2008

• S. Jimenez
• et al

Amyloid-β peptide binds to microtubule-associated protein 1B (MAP1B)

Neurochem Int . 2008 May 01 ; 52(6) 1030 | DOI : https://doi.org/10.1016/j.neuint.2007.10.020

• G. Gevorkian
• et al

Spatial Memory Impairment Without Apoptosis Induced by the Combination of Beta-Amyloid Oligomers and Cerebral Ischemia Is Related to Decreased Acetylcholine Release in Rats

J Pharmacol Sci . 2007 Nov 13 ; 106 84 | DOI : 10.1254/jphs.fp0071648

• T. Watanabe
• et al

Aβ 1-42 Induces Mild Endoplasmic Reticulum Stress in an Aggregation State–Dependent Manner

Antioxid Redox Signal. . 2007 Dec 01 ; 9(12) 2245 | DOI : 10.1089/ars.2007.1797

• SM. Chafekar
• et al

Cholinergic dysfunction in a mouse model of Alzheimer disease is reversed by an anti-Aβ antibody

J Clin Invest. . 2006 Mar 01 ; 116(3) 825 | DOI : https://doi.org/10.1172/JCI27120.

• KR. Bales
• et al

Aβ and tau form soluble complexes that may promote self aggregation of both into the insoluble forms observed in Alzheimer's disease

PNAS . 2006 Feb 07 ; 103(6) 1953 | DOI : https://doi.org/10.1073/pnas.0509386103

• J-P. Guo
• et al

CLAC Binds to Amyloid β Peptides through the Positively Charged Amino Acid Cluster within the Collagenous Domain 1 and Inhibits Formation of Amyloid Fibrils

JBC . 2004 Dec 21 ; 280 15484 | DOI : 10.1074/jbc.M413340200

• Y. Osada
• et al

Aβ-polyacrolein aggregates: Novel mechanism of plastic formation in senile plaques

BBRC . 2005 Dec 23 ; 335(2) 501 | DOI : https://doi.org/10.1016/j.bbrc.2005.07.111

• N. Seidler
• TJ. Squire

Role of Phenylalanine 20 in Alzheimer's Amyloid β-Peptide (1-42)-Induced Oxidative Stress and Neurotoxicity

Chem. Res. Toxicol. . 2004 Nov 24 ; 17(12) 1743 | DOI : https://doi.org/10.1021/tx049796w

• D. Boyd-Kimball
• et al

Effect of Different Anti-Aβ Antibodies on Aβ Fibrillogenesis as Assessed by Atomic Force Microscopy

JMB . 2004 Jan 23 ; 335(4) 997 | DOI : https://doi.org/10.1016/j.jmb.2003.11.019

• J. Legleiter
• et al

Epitope and isotope specificities of antibodies to β-amyloid peptide for protection against Alzheimer's disease-like neuropathology

PNAS . 2004 Aug 03 ; 101(31) 11526 | DOI : 10.1073/pnas.0436286100

• F. Bard
• et al

Role of high mobility group protein-1 (HMG1) in amyloid-β homeostasis

BBRC . 2003 Feb 14 ; 301(3) 699 | DOI : https://doi.org/10.1016/S0006-291X(03)00024-X

• K. Takata
• et al

β-amyloid-specific upregulation of stearoyl coenzyme A desaturase-1 in macrophages

BBRC . 2003 Mar 28 ; 303(1) 302 | DOI : https://doi.org/10.1016/S0006-291X(03)00334-6

• S. Uryu
• et al

Plasma membrane cholesterol controls the cytotoxicity of Alzheimer’s disease AβP (1–40) and (1–42) peptides

FASEB J . 2002 Oct 02 ; 16(12) 1526 | DOI : 10.1096/fj.02-0829com

• N. Arispe
• M. Doh

The hydrophobic environment of Met35 of Alzheimer's Aβ(1–42) is important for the neurotoxic and oxidative properties of the peptide

Neurotox Res . 2002 May 01 ; 4(3) 219 | DOI : 10.1080/10298420290023945

• J. Kanski
• et al

Activation of microglia by secreted amyloid precursor protein evokes release of glutamate by cystine exchange and attenuates synaptic function

J Neurochem. . 2001 Feb 01 ; 76(3) 846 | DOI : 10.1046/j.1471-4159.2001.00075.x

• SW. Barger
• AS. Basile

The Ginkgo biloba extract EGb 761 rescues the PC12 neuronal cells from β-amyloid-induced cel death by inhibiting the formation of β-derived diffusible neurotoxic ligands

Brain Res . 2001 Jan 19 ; 889(1-2) 181 | DOI : https://doi.org/10.1016/S0006-8993(00)03131-0

• Z-X. Yao
• et al

Vitamin E Prevents Alzheimer's Amyloid beta-Peptide (1-42)-Induced Neuronal Protein Oxidation and Reactive Oxygen Species Production.

J Alzheimers Dis . 2000 Jun 01 ; 2(2) 123 | DOI : 10.3233/jad-2000-2212

• SM. Yatin
• et al

Free radicals and lipid peroxidation do not mediate β-amyloid-induced neuronal cell death

Brain Res . 1999 Nov 20 ; 847(2) 203 | DOI : https://doi.org/10.1016/S0006-8993(99)02047-8

• Z-X. Yao
• et al

Autophagy is involved in oligodendroglial precursor-mediated clearance of amyloid peptide

Mol Neurodegener . 2013 Aug 10 ; 8 22 | DOI : 10.1186/1750-1326-8-27

• W. Li
• et al

The NALP3 inflammasome is involved in the innate immune response to amyloid-β

Nat Immunol. . 2008 Jul 11 ; 9(8) 857 | DOI : 10.1038/ni.1636

• A. Halle
• et al

Effects of hydroxyl group variations on a flavonoid backbone toward modulation of metal-free and metal-induced amyloid-β aggregation

Inorg. Chem. Front. . 2016 Jan 13 ; 3 381 | DOI : 10.1039/C5QI00219B

• HJ. Lee
• et al

Effects of NK-4 in a Transgenic Mouse Model of Alzheimer's Disease

PLoS One. . 2012 Jan 04 ; 7(1) e30007 | DOI : https://doi.org/10.1371/journal.pone.0030007

• H. Ohta
• et al

Microglial Amyloid-β1-40 Phagocytosis Dysfunction is Caused by High-Mobility Group Box Protein-1: Implications for the Pathological Progression of Alzheimer’s Disease

Int J Alz Dis . 2012 May 08 ; 2012 685739 | DOI : https://doi.org/10.1155/2012/685739

• K. Takata
• et al

Gelsolin Restores Aβ-Induced Alterations in Choroid Plexus Epithelium

J Biomed Biotechnol . 2010 Mar 25 ; 2010 805405 | DOI : https://doi.org/10.1155/2010/805405

• T. Vargas
• et al

The cleavage products of amyloid-β precursor protein are sorted to distinct carrier vesicles that are independently transported within neurites

J Neurosci.  . 2009 Mar 18 ; 29(11) 3565 | DOI : 10.1523/JNEUROSCI.2558-08.2009

• V. Muresan
• et al

Enzymatic characteristics of I213T mutant presenilin-1/gamma-secretase in cell models and knock-in mouse brains: familial Alzheimer disease-linked mutation impairs gamma-site cleavage of amyloid precursor protein C-terminal fragment beta.

J Biol Chem . 2008 Apr 21 ; 283(24) 16488 | DOI : 10.1074/jbc.M801279200

• M. Shimojo
• et al

Early-onset behavioral and synaptic deficits in a mouse model of Alzheimer's disease

PNAS . 2006 Mar 28 ; 103(13) 5161 | DOI : https://doi.org/10.1073/pnas.0600948103

• JS. Jacobsen
• et al

Glypican-1 as an Aβ binding HSPG in the human brain: Its localization in DIG domains and possible roles in the pathogenesis of Alzheimer’s disease

FASEB J . 2004 Apr 14 ; 18(9) | DOI : https://doi.org/10.1096/fj.03-1040fje

• N. Watanabe

A novel compound RS-0466 reverse β-amyloid-induced cytotoxcity through the Akt signaling pathway in vitro

Eur J Pharmacol. . 2012 Dec 13 ; 457(1) 11 | DOI : 10.1016/s0014-2999(02)02657-2

• Y. Nakagami
• et al

Interaction between β-amyloid and lens αB-crystallin

FEBS Lett . 2000 Nov 03 ; 484(2) 98 | DOI : https://doi.org/10.1016/S0014-5793(00)02136-0

• JJN. Liang
• et al

Complement-dependent proinflammatory properties of the Alzheimer's disease β-peptide

JEM . 1998 Aug 03 ; 188(3) 431 | DOI : https://doi.org/10.1084/jem.188.3.431

• BM. Bradt
• et al

N‐terminal truncated pyroglutamyl β amyloid peptide Aβpy3‐42 shows a faster aggregation kinetics than the full‐length Aβ1‐42.

Biopolymers . 2009 Oct 01 ; 91(10) 861 | DOI : 10.1002/bip.21271

• C. D'Arrigo

Effect on memory of acute administration of naturally secreted fibrils and synthetic amyloid-beta peptides in an invertebrate model.

Neurobiol Learn Mem . 2007 Oct 24 ; 89(4) 407 | DOI : 10.1016/j.nlm.2007.08.011

• M. Feld
• et al

β-Amyloid is different in normal aging and in Alzheimer disease.

J. Biol. Chem. . 2015 Aug 15 ; 280(40) 34186 | DOI : 10.1074/jbc.M501694200

• A. Piccini
• et al

Microchip electrophoresis profiling of Aβ peptides in the cerebrospinal fluid of patients with Alzheimer’s disease.

Anal Chem . 2010 Sep 15 ; 82(18) 7611 | DOI : 10.1021/ac101337n

• M. Reza
• et al

Formation of Amyloids by Aβ-(1–42) on NGF-differentiated PC12 Cells: Roles of Gangliosides and Cholesterol.

J. Mol. Biol. . 2007 Jun 09 ; 371(4) 924 | DOI : 10.1016/j.jmb.2007.06.008

• M. Wakabayashi
• et al

N-truncation and pyroglutaminylation enhances the opsonizing capacity of Aβ-peptides and facilitates phagocytosis by macrophages and microglia.

Brain Behav Immun . 2014 May 27 ; 41 116 | DOI : 10.1016/j.bbi.2014.05.003.

• M. Condic
• et al

Protection against β-Amyloid-induced Apoptosis by Peptides Interacting with β-Amyloid.

J Biol Chem . 2007 Aug 30 ; 283 6616 | DOI : 10.1074/jbc.M705558200

• TJ. Nelson
• DL. Alkon

Alzheimer's amyloid β-peptide associated free radicals increase rat embryonic neuronal polyamine uptake and ornithine decarboxylase activity: protective effect of vitamin E.

Neurosci Lett . 1999 Mar 19 ; 263(1) 17 | DOI : 10.1016/s0304-3940(99)00101-9

• S. Yatin
• et al

Measurement of anti-Aβ1–42 antibodies in intravenous immunoglobulin with indirect ELISA: The problem of nonspecific binding.

J Neurosci Methods . 2010 Jan 25 ; 187(2) 263 | DOI : 10.1016/j.jneumeth.2010.01.018

• A. Klaver
• et al

Competitive electrochemical immunosensor for amyloid-beta 1-42 detection based on gold nanostructurated screen-printed carbon electrodes.

Sensors Actuators B: Chem . 2014 Oct 01 ; 201 567 | DOI : 10.1016/j.snb.2014.05.044.

• EC. Rama
• et al

Protection against beta-amyloid induced apoptosis by peptides interacting with beta-amyloid.

J Biol Chem . 2007 Aug 30 ; 282(43) 31238 | DOI : 10.1074/jbc.M705558200 (2007).

• TJ. Nelson
• DL. Alkon

β -Secretase-Cleaved Amyloid Precursor Protein Accumulates at Actin Inclusions Induced in Neurons by Stress or Amyloid β : A Feedforward Mechanism for Alzheimer’s Disease

J Neurosci. . 2005 Dec 07 ; 25(49) 11313 | DOI : https://doi.org/10.1523/JNEUROSCI.3711-05.2005

• MT. Maloney
• et al

Epitope mapping and neuroprotective properties of a human single chain FV antibody that binds an internal epitope of amyloid-beta 1-42

Molecular Immuno . 2008 Feb 01 ; 45(4) 881 | DOI : https://doi.org/10.1016/j.molimm.2007.08.008

• RS. Solorzano-Vargas
• et al