Parathyroid hormone related Peptides

Calcium Homeostasis

Calcium homeostasis is finely regulated by Parathyroid Hormone (PTH), Calcitonin and Vitamin D.

A decrease in blood calcium concentration triggers the release of PTH from the parathyroid glands. This 84-amino acid hormone plays important roles in calcium homeostasis of bone, kidney, breast, and placenta. PTH signals via the PTH/PTHrP and PTH2 receptors. PTH (1–34) administration suppresses cardiovascular calcification and down-regulates aortic osteogenic programs driven by diabetes and dyslipidemia.

An increase of calcium concentration, stimulates the release of Calcitonin, a 32-amino acid peptide from the thyroid parafollicular cells (C-cells).

References

• Khan, MM. and Desborough JP. , Pharmacology 19, 1 (2005)
• Stevenson, RW andParsons JA , J. Endo. 97, 21 (1983)
• Newman, W. et al. J. Biol. Chem. 264, 16359 (1989)
• Brennan, DP. and  Levine MA., J. Biol. Chem. 262, 14795 (1987)
• Broadus, AE. et al. N. Engl. J. Med. 319, 556 (1988)