SensoLyte® Generic MMP Assay Kit Colorimetric - 1 kit
- Cat.Number : AS-72095
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Matrix metalloproteinases (MMPs) belong to a family of secreted or membrane-associated proteins capable of digesting extracellular matrix components. The importance of MMPs in tumor development and invasion as well as other diseases is well known.
The SensoLyte® Generic MMP Assay Kit can be used to detect the activity of a variety of MMPs, including MMP-1, 2, 3, 7, 8, 9, 12, 13, and 14 or for high throughput screening of MMPs’ inducers and inhibitors. The substrate is a thiopeptolide that is cleaved by the MMPs, releasing a sulfhydryl group, which can be detected with a color-developing thiol-reactive agent, 4,4’-dithiodipyridine or Ellman’s Reagent at 412 nm using a microplate reader. The assays are performed in a convenient 96-well microplate format.
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Citations
Carbodiimide cross-linking inactivates soluble and matrix-bound MMPs, in vitro JDR 91, 192-196
J Dent Res . 2012 Feb 01 ; 91 192 | DOI : 10.1177/0022034511427705
- A. Tezvergil-Mutluay
- et al
Inhibition of endogenous dentin matrix metalloproteinases by ethylenediaminetetraacetic acid
J Endod . 2011 Nov 03 ; 38 62 | DOI : 10.1016/j.joen.2011.09.005
- J. Thompson
- et al
The Inhibitory Effects of Quaternary Ammonium Methacrylates on Soluble and Matrix-bound MMPs
J Dent Res . 2011 Apr 01 ; 90 535 | DOI : 10.1177/0022034510389472
- A. Tezvergil-Mutluay
- et al
The inhibitory effect of polyvinylphosphonic acid on functional MMP activities in human demineralized dentin
Acta Biomater . 2010 May 23 ; 6 4136 | DOI : 10.1016/j.actbio.2010.05.017
- A. Tezvergil-Mutluay
- et al