SensoLyte® AFC Thrombin Activity Assay Kit Fluorimetric - 1 kit
- Cat.Number : AS-72130
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Thrombin, a serine protease, plays a central role in hemostasis by converting soluble plasma fibrinogen into an insoluble fibrin clot and by promoting platelet aggregation. Thrombin also influences a number of normal and pathological processes, including inflammation, tissue repair, embryogenesis, angiogenesis, and tumor invasion.
The SensoLyte® AFC Thrombin Assay Kit is optimized for screening of enzyme inhibitors. This kit contains a fluorogenic substrate which shows high reactivity and low background. Thrombin cleaves the substrate resulting in the release of the AFC (7-amido-4-trifluoromethylcoumarin) fluorophore. Fluorescence can be monitored at excitation/emission= 380 nm/500 nm. The assays are performed in a convenient 96-well or 384-well microplate format.
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Citations
Reactive Center Loop (RCL) Peptides Derived from Serpins Display Independent Coagulation and Immune Modulating Activities.
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- et al
Interleukin-1 promotes coagulation, which Is necessary for protective immunity in the lung against Streptococcus pneumoniae infection
J Infect Dis . 2013 Jan 01 ; 207(1) 50 | DOI : 10.1093/infdis/jis651
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- et al
Intravenous and oral administrations of DD2 [7-Amino-2-
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- T. Sasaki
- et al
Novel agmatine and agmatine-like peptidomimetic inhibitors of the West Nile Virus NS2B/NS3 serine protease
Eur J Med Chem . 2011 Apr 28 ; 46(7) 3130 | DOI : 10.1016/j.ejmech.2011.04.055
- H.A. Lim
- et al