Protease-Activated Receptor-3, PAR-3 (1-6), human - 1 mg
- Cat.Number : AS-62657
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This is amino acids 1 to 6 fragment of the protease-activated receptor 3 (PAR-3). This synthetic peptide induces ERK activation in human carcinoma cells endogeneously expressing PAR-1 and PAR-3. This effect is completely abolished by single alanine substitution at positions 3, 4 and 6 in the peptide. PAR-3 allosterically regulates PAR-1 signaling by receptor dimerization governing increased endothelial permeability. Targeting of PAR-3 may mitigate the effects of PAR-1 in activating endothelial responses such as vascular inflammation. However this peptide does not affect VEGF release or expression.
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Citations
Thrombin- and Factor Xa–induced DNA synthesis is mediated by transactivation of fibroblast growth factor receptor-1 in human vascular smooth muscle cells.
Circ. Res . 2003 Dec 11 ; 94(3) 340 | DOI : 10.1161/01.RES.0000111805.09592.D8
- BH. Rauch
- et al
Thrombin and factor Xa-induced DNA synthesis is mediated by transactivation of fibroblast growth factor receptor-1 in human vascular smooth muscle cells
Circ Res. . 2003 Dec 11 ; 94(3) 340 | DOI : 10.1161/01.RES.0000111805.09592.D8
- BH. Rauch
- et al