Protease-Activated Receptor-1, PAR-1 Agonist - 1 mg
- Cat.Number : AS-61530
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Protease activated receptor 1 (PAR-1) belongs to a subfamily of G-protein coupled receptors and is known to mediate the cellular effects of thrombin. This protease-activated receptor-1 (PAR-1) selective peptide induces cyclooxygenase-2 (COX-2) protein and mRNA expression in human endothelial cells. Studies show that intratracheal instillation of the PAR1-specific peptide increases lung edema during high-tidal-volume ventilation
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Citations
Chronic exposure to fibrin and fibrinogen differentially regulates intracellular Ca2+ in human pulmonary arterial smooth muscle and endothelial cells.
Am J Physiol Lung Cell Mol Physiol. . 2009 Apr 10 ; 296(6) L979 | DOI : 10.1152/ajplung.90412.2008
- AL. Firth
- et al
Thrombin- and Factor Xa–induced DNA synthesis is mediated by transactivation of fibroblast growth factor receptor-1 in human vascular smooth muscle cells.
Circ. Res . 2003 Dec 11 ; 94(3) 340 | DOI : 10.1161/01.RES.0000111805.09592.D8
- BH. Rauch
- et al
Effect of thrombin on human amnion mesenchymal cells, mouse fetal membranes, and preterm birth
J Biol Chem. . 2014 Mar 20 ; 289(19) 13295 | DOI : 10.1074/jbc.M114.550541
- H. Mogami
- et al
Cathepsin G recruits osteoclast precursors via proteolytic activation of protease-activated receptor-1
Cancer Res . 2009 Mar 17 ; 69(7) 3188 | DOI : 10.1158/0008-5472.CAN-08-1956
- TJ. Wilson
- et al
Ligation of protease-activated receptor 1 enhances αv β6 integrin–dependent TGF-β activation and promotes acute lung injury
J Clin Invest. . 2006 May 18 ; 116(6) 1606 | DOI : 10.1172/JCI27183
- RG. Jenkins
- et al
Thrombin and factor Xa-induced DNA synthesis is mediated by transactivation of fibroblast growth factor receptor-1 in human vascular smooth muscle cells
Circ Res. . 2003 Dec 11 ; 94(3) 340 | DOI : 10.1161/01.RES.0000111805.09592.D8
- BH. Rauch
- et al
Protease-activated receptors 1 and 4 mediate thrombin signaling in endothelial cells
Blood . 2003 Jul 17 ; 102(9) 3224 | DOI : 10.1182/blood-2003-04-1130
- H. Kataoka
- et al