Tube of Prosaptide TX14(A) peptide
Peptides

Prosaptide TX14(A)

€127.00
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  • Cat.Number : AS-60248-1
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This 14-mer prosaptide sequence is derived from the active neurotrophic region in the amino-terminal portion of the saposin C domain. Synthetic peptides derived from this region are biologically active and are named “prosaptides.” Prosaposin and prosaptides are active on a variety of neuronal cells, stimulating sulfatide synthesis and increasing sulfatide concentration in Schwann cells and oligodendrocytes. This indicates that prosaposin and prosaptides are trophic factors for myelin formation.

Specifications

Chemistry
Sequence one letter code
  • TaLIDNNATEEILY
Sequence three letter code
  • H-Thr-D-Ala-Leu-Ile-Asp-Asn-Asn-Ala-Thr-Glu-Glu-Ile-Leu-Tyr-OH
CAS registry number
  • 196391-82-9
Molecular Formula
  • C69H110N16O26
Molecular Mass/ Weight
  • 1579.8
Modification
Conjugation
  • Unconjugated
Quantity & Purity
Purity
Storage & stability
Form
  • Lyophilized
Storage Conditions
  • - 20 °C
Activity
Biomarker Target
Research Area
Sub-category Research Area
Usage
  • Research use
Codes
Code Nacres
  • NA.26

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Citations

Protection of sensory function and antihyperalgesic properties of a prosaposin-derived peptide in diabetic rats

Anesthesiology. . 2000 Nov 01 ; 93(5) 1271 | DOI : 10.1097/00000542-200011000-00021

  • NA. Calcutt
  • et al

Reversal of thermal hyperalgesia in a rat partial sciatic nerve ligation model by Prosaptide™ TX14(A)

Neurosci Lett . 1999 Jul 23 ; 270(1) 29 | DOI : https://doi.org/10.1016/S0304-3940(99)00461-9

  • D. Otero
  • et al

Prosaptide activates the MAPK pathway by a G-protein-dependent mechanism essential for enhanced sulfatide synthesis by Schwann cells

FASEB J . 1998 Mar 01 ; 12(3) 307 | DOI : 10.1096/fasebj.12.3.307

  • WM. Campana
  • et al

Cell death prevention, mitogen-activated protein kinase stimulation, and increased sulfatide concentrations in Schwann cells and oligodendrocytes by prosaposin and prosaptides

Proc Natl Acad Sci U S A . 1997 Apr 29 ; 94(9) 4778 | DOI : 10.1073/pnas.94.9.4778

  • M. Hiraiwa
  • et al

GPR37 and GPR37L1 are receptors for the neuroprotective and glioprotective factors prosaptide and prosaposin

Proc Natl Acad Sci U S A. . 2013 May 20 ; 110(23) 9529 | DOI : 10.1073/pnas.1219004110

  • RC. Meyer
  • et al