Prosaptide TX14(A)
- Cat.Number : AS-60248-1
- Manufacturer Ref. :
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This 14-mer prosaptide sequence is derived from the active neurotrophic region in the amino-terminal portion of the saposin C domain. Synthetic peptides derived from this region are biologically active and are named “prosaptides.” Prosaposin and prosaptides are active on a variety of neuronal cells, stimulating sulfatide synthesis and increasing sulfatide concentration in Schwann cells and oligodendrocytes. This indicates that prosaposin and prosaptides are trophic factors for myelin formation.
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Citations
Protection of sensory function and antihyperalgesic properties of a prosaposin-derived peptide in diabetic rats
Anesthesiology. . 2000 Nov 01 ; 93(5) 1271 | DOI : 10.1097/00000542-200011000-00021
- NA. Calcutt
- et al
Reversal of thermal hyperalgesia in a rat partial sciatic nerve ligation model by Prosaptide™ TX14(A)
Neurosci Lett . 1999 Jul 23 ; 270(1) 29 | DOI : https://doi.org/10.1016/S0304-3940(99)00461-9
- D. Otero
- et al
Prosaptide activates the MAPK pathway by a G-protein-dependent mechanism essential for enhanced sulfatide synthesis by Schwann cells
FASEB J . 1998 Mar 01 ; 12(3) 307 | DOI : 10.1096/fasebj.12.3.307
- WM. Campana
- et al
Cell death prevention, mitogen-activated protein kinase stimulation, and increased sulfatide concentrations in Schwann cells and oligodendrocytes by prosaposin and prosaptides
Proc Natl Acad Sci U S A . 1997 Apr 29 ; 94(9) 4778 | DOI : 10.1073/pnas.94.9.4778
- M. Hiraiwa
- et al
GPR37 and GPR37L1 are receptors for the neuroprotective and glioprotective factors prosaptide and prosaposin
Proc Natl Acad Sci U S A. . 2013 May 20 ; 110(23) 9529 | DOI : 10.1073/pnas.1219004110
- RC. Meyer
- et al