[Lys(Me3)4]-Histone H3 (1-21)-GGK(Biotin)-NH2 - 1 mg
- Cat.Number : AS-64192
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This peptide is a synthetic peptide corresponding to amino acids 1-21 of human histone H3. It is trimethylated at lysine-4 with a C-terminal Gly-Gly linker followed by a biotinylated Lys. The trimethylation of histone H3 at lysine 4 [H3K4(Me3)] shows cell state and lineage potential by differentiating genes that are expressed, poised for expression, or repressed. H3K4(Me3) also labels imprinting control regions.
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Citations
MeCP2 binds to nucleosome free (linker DNA) regions and to H3K9/H327 methylated nucleosomes in brain.
Nucl Acids Res . 2011 Dec 05 ; 40(7) 2884 | DOI : 10.1093/nar/gkr1066.
- AA. Thambirajah
- et al