LL-37, Antimicrobial Peptide, human - 1 mg
- Cat.Number : AS-61302
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Antimicrobial peptide LL-37, belonging to the cathelicidin family, is the first amphipathic alpha-helical peptide isolated from human. It plays an important role in the first line of defense against local infection and systemic invasion of pathogens at sites of inflammation and wounds. Cytotoxic to both bacterial and normal eukaryotic cells , LL-37 is significantly resistant to proteolytic degradation in solution.
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Citations
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Vitamin D and the Human Antimicrobial Peptide LL-37 Enhance Group A Streptococcus Resistance to Killing by Human Cells
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The bone marrow-expressed antimicrobial cationic peptide LL-37 enhances the responsiveness of hematopoietic stem progenitor cells to an SDF-1 gradient and accelerates their engraftment after transplantation
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Susceptibility of Pseudomonas aeruginosa Biofilm to Alpha-Helical Peptides: D-enantiomer of LL-37
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Exopolysaccharides of Lactobacillus rhamnosus GG form a protective shield against innate immune factors in the intestine
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The dlt operon confers resistance to cationic antimicrobial peptides in Clostridium difficile
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Real-time attack on single Escherichia coli cells by the human antimicrobial peptide LL-37
PNAS . 2011 Apr 04 ; 108(16) E77 | DOI : 10.1073/pnas.1101130108
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- et al
Mas-related gene X2 (MrgX2) is a novel G protein-coupled receptor for the antimicrobial peptide LL-37 in human mast cells: resistance to receptor phosphorylation, desensitization, and internalization.
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Fluorescence and UV Resonance Raman Study of Peptide−Vesicle Interactions of Human Cathelicidin LL-37 and Its F6W and F17W Mutants
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Suppressive effect of the antimicrobial peptide LL‐37 on expression of IL‐6, IL‐8 and CXCL10 induced by Porphyromonas gingivalis cells and extracts in human gingival fibroblasts
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Antibacterial effect of human mesenchymal stem cells is mediated in part from secretion of the antimicrobial peptide LL-37.
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Burkholderia cenocepacia zinc metalloproteases influence resistance to antimicrobial peptides.
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LL-37 via EGFR Transactivation to Promote High Glucose–Attenuated Epithelial Wound Healing in Organ-Cultured Corneas
Invest Ophthalmol Vis Sci. . 2009 Sep 24 ; 51(4) 1891 | DOI : 10.1167/iovs.09-3904
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Toxins and antimicrobial peptides: interactions with membranes
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Impaired mobilization of hematopoietic stem/progenitor cells in C5-deficient mice supports the pivotal involvement of innate immunity in this process and reveals novel promobilization effects of granulocytes
Leukemia. . 2009 Aug 06 ; 23(11) 2052 | DOI : 10.1038/leu.2009.158
- HM. Lee
- et al
Acyl carrier protein is a bacterial cytoplasmic target of cationic antimicrobial peptide LL-37
Biochem J . 2015 Jul 17 ; 470(2) 243 | DOI : 10.1042/BJ20150432.
- MC. Chung
- et al
Chlamydial plasmid-encoded virulence factor Pgp3 neutralizes the antichlamydial activity of human cathelicidin LL-37
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Decreased outer membrane permeability protects mycobacteria from killing by ubiquitin-derived peptides.
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Clostridium difficile clinical isolates exhibit variable susceptibility and proteome alterations upon exposure to mammalian cationic antimicrobial peptides.
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Structure–activity relationship of human liver-expressed antimicrobial peptide 2.
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β-Defensins activate human mast cells via Mas-Related Gene X2.
J Immunol . 2013 May 22 ; 191(1) 345 | DOI : 10.4049/jimmunol.1300023.
- H. Subramanian
- et al
Fluorescence and UV resonance Raman study of peptide−vVesicle interactions of human cCathelicidin LL-37 and its F6W and F17W mutants
Biochem . 2009 Dec 01 ; 48(47) 11264 | DOI : 10.1021/bi900996q.
- JE. Gable
- et al