Tube of gp91 ds-tat Peptide
Peptides

gp91 ds-tat, NADPH oxidase inhibitor - 1 mg

€158.00
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  • Cat.Number : AS-63818
  • Availability :
    In production

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In the kidney, there are many enzymatic systems that contribute to the production of Reactive Oxygen Species, including nicotinamide adenine dinucleotide phosphate (NADPH) oxidase. NADPH oxidase has been considered as the major source of superoxide in the kidney, and its action relies on an enzymatic complex with five subunits, including gp91phox.
This peptide is composed of gp91phox sequence linked to the human immunodeficiency virus-tat peptide. The tat sequence facilitates the entry of this peptide into all cells. It is used as a peptide inhibitor for NADPH oxidase assembly.

Specifications

Chemistry
Sequence one letter code
  • YGRKKRRQRRRCSTRIRRQL-NH2
Sequence three letter code
  • H-Tyr-Gly-Arg-Lys-Lys-Arg-Arg-Gln-Arg-Arg-Arg-Cys-Ser-Thr-Arg-Ile-Arg-Arg-Gln-Leu-NH2
Molecular Formula
  • C109H202N52O25S1
Molecular Mass/ Weight
  • 2673.3
Modification
Conjugation
  • Unconjugated
Quantity & Purity
Purity
Storage & stability
Form
  • Lyophilized
Storage Conditions
  • - 20 °C
Activity
Application
Biomarker Target
Research Area
Sub-category Research Area
Usage
  • Research use
Source
Source / Species
  • HIV
Codes
Code Nacres
  • NA.26

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Citations

L-type Ca2+ channel contributes to alterations in mitochondrial calcium handling in the mdx ventricular myocyte.

Am J Physiol Heart Circ Physiol . 2013 Mar 15 ; 304(6) H767 | DOI : 10.​1152/​ajpheart.​00700.​2012.

  • H. Viola
  • et al

Endothelial angiogenesis and barrier function in response to thrombin requires Ca2+ influx through the Na+/Ca2+ exchanger

J Biol Chem . 2015 May 15 ; 290(30) 18412 | DOI : 10.1074/jbc.M114.628156.

  • P. Andrikopoulos
  • et al

Prolonged exposure of cortical neurons to oligomeric amyloid-beta impairs NMDA receptor function via NADPH oxidase-mediated ROS production: protective effect of green tea (-)-epigallocatechin-3-gallate.

ASN Neuro . 2011 Feb 08 ; 3(1) e00050 | DOI : 10.1042/AN20100025.

  • Y. He
  • et al

High-Frequency field stimulation of primary neurons enhances ryanodine receptor-mediated Ca2+ release and generates hydrogen peroxide, which jointly stimulate NF-kB activity.

Antioxid Redox Signaling . 2010 Sep 13 ; 14(7) 1245 | DOI : 10.1089/ars.2010.3238.

  • D. Riquelme
  • et al

Phosphoinositide 3-kinase mediates CD40 ligand-induced oxidative stress and endothelial dysfunction via Rac1 and NADPH oxidase 2.

J Thromb Haemost. . 2009 Nov 06 ; 8(2) 397 | DOI : 10.1111/j.1538-7836.2009.03683.x.

  • M. Xia
  • et al