Endothelin 1, human, porcine, bovine, mouse, rat
- Cat.Number : AS-22859
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ET-1 is a potent vasoconstrictor peptide derived from endothelial cells. It plays a role in regulation of cardiovascular functions. The binding of ET-1 to G-protein coupled receptor triggers a signal transduction cascade leading to activation of the protein kinase C (PKC). PKC inhibitor potentially reverses the up regulation of ET-1. The enhanced ET-1 expression associated with the activation of PKC occurs in early diabetes.
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Citations
Equal contribution of increased intracranial pressure and subarachnoid blood to cerebral blood flow reduction and receptor upregulation after subarachnoid hemorrhage. Laboratory investigation.
J Neurosurg . 2009 Nov 01 ; 111(5) 978 | DOI : 10.3171/2007.3.16738
- S. Ansar
- et al
Neurogenesis Associated with Endothelin-induced Cortical Infarction in the Mouse
Brain Res . 2008 Sep 05 ; 1167 118 | DOI : 10.1016/j.brainres.2007.06.065
- Y. Wang
- et al
Endothelin-1 Attenuates Apoptosis in Cultured Trophoblasts From Term Human Placentas.
Reprod Sci . 2007 Dec 31 ; 14(5) 430 | DOI : https://doi.org/10.1177/1933719107305801
- M. Cervar-Zivkovic
- et al
ERK1/2 inhibition attenuates cerebral blood flow reduction and abolishes ET(B) and 5-HT(1B) receptor upregulation after subarachnoid hemorrhage in rat.
J Cereb Blood Flow Metab. . 2006 Jun 01 ; 26(6) 846 | DOI : 10.1038/sj.jcbfm.9600236
- SA. Beg
- et al
Neurokinin-1 receptor antagonism in a rat model of subarachnoid hemorrhage: prevention of upregulation of contractile ETB and 5-HT1B receptors and cerebral blood flow reduction.
J Neurosurg. . 2007 May 01 ; 106(5) 881 | DOI : 10.3171/jns.2007.106.5.881
- S. Ansar
- et al