[D-Tyr6, ß-Ala11, Phe13, Nle14]-Bombesin (6-14) - 1 mg
- Cat.Number : AS-60134-1
- Manufacturer Ref. :
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This peptide is a universal Bombesin synthetic ligand, binding to all 3 bombesin receptors.
Bombesin is a 14-aa peptide originally isolated from the fire-bellied toad. It has two mammalian homologs, neuromedin and Gastrin-Releasing Peptide (GRP). It binds with high affinity to the GRP receptor, a member of the G-protein-coupled receptor family. It stimulates gastrin release from G cells, and acts in the brain to stop eating behavior. Bombesin is also a tumor marker for lung small cell carcinoma, neuroblastoma, pancreatic cancer and gastric cancer.
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Citations
Effect of bombesin receptor subtype-3 and its synthetic agonist on signaling, glucose transport and metabolism in myocytes from patients with obesity and type 2 diabetes.
Intl J Mol Med . 2015 Feb 04 ; 35(4) 925 | DOI : 10.3892/ijmm.2015.2090
- N. González
- et al