ADAMTS-4/Aggrecanase FRET Substrate, WAAG-3R - 1 mg
- Cat.Number : AS-60431-1
- Manufacturer Ref. :
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Aggrecanases belong to the ADAMTS (A disintegrin and metalloprotease with thrombospondin motif) family of proteases. Aggrecanases cleave aggrecan, the major structural component of cartilage. Aggrecanase-1 (ADAMTS-4) is a major aggrecanase in human osteoarthritic cartilage.
This FRET peptide was used in an ADAMTS-4 (Aggrecanase-1) assay. Ex/Em = 340/420 nm.
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Citations
The Design and Synthesis of Novel N-hydroxyformamide inhibitors of ADAM-TS4 for the treatment of osteoarthritis
Bioorg Med Chem Lett. . 2011 Jan 18 ; 21(5) 1376 | DOI : 10.1016/j.bmcl.2011.01.036
- C. Savi
- et al