520 MMP FRET Substrate 13 - 0.1 mg
- Cat.Number : AS-60580-01
- Manufacturer Ref. :
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Matrix Metalloproteinases (MMPs) are a large family of endopeptidases. Collectively, MMPs can degrade all kinds of extracellular matrix proteins, and can also process a number of bioactive molecules. They are known to be involved in the cleavage of cell surface receptors, the release of apoptotic ligands, and chemokine/cytokine inactivation. MMPs are also thought to play a major role in cell behaviors such as cell proliferation, migration (adhesion/dispersion), differentiation, angiogenesis, apoptosis, and host defense.
This peptide is a sensitive substrate for assaying MMP-3 and 12 activities, Abs/Em = 494/521 nm.
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Citations
Cyclooxygenase inhibition limits blood-brain barrier disruption following intracerebral injection of tumor necrosis factor-α in the rat.
J Pharmacol Exp Ther . 2007 Aug 17 ; 323(2) 488 | DOI : 10.1124/jpet.107.127035
- E. Candelario-Jalil
- et al