520 MMP FRET Substrate 6 - 0.1 mg
- Cat.Number : AS-60573-01
- Manufacturer Ref. :
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Matrix Metalloproteinases (MMPs) are a large family of endopeptidases. Collectively, MMPs can degrade all kinds of extracellular matrix proteins, and can also process a number of bioactive molecules. They are known to be involved in the cleavage of cell surface receptors, the release of apoptotic ligands, and chemokine/cytokine inactivation. MMPs are also thought to play a major role in cell behaviors such as cell proliferation, migration (adhesion/dispersion), differentiation, angiogenesis, apoptosis, and host defense.
This peptide is a sensitive substrate for assaying MMP-2 and 13 activities, Abs/Em = 494/521 nm.
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Citations
Divergent role for MMP-2 in myelin breakdown and oligodendrocyte death following transient global ischemia.
J Neurosci Res . 2010 Mar 01 ; 88(4) 764 | DOI : 10.1002/jnr.22257
- E. Walker
- et al