520 MMP FRET Substrate 14 - 0.1 mg
- Cat.Number : AS-60581-01
- Manufacturer Ref. :
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Matrix Metalloproteinases (MMPs) are a large family of endopeptidases. Collectively, MMPs can degrade all kinds of extracellular matrix proteins, and can also process a number of bioactive molecules. They are known to be involved in the cleavage of cell surface receptors, the release of apoptotic ligands, and chemokine/cytokine inactivation. MMPs are also thought to play a major role in cell behaviors such as cell proliferation, migration (adhesion/dispersion), differentiation, angiogenesis, apoptosis, and host defense.
This peptide is a sensitive substrate for assaying MMP-1, 2, 3, 7, 8, 9, 12, and 13 activities, Abs/Em = 494/521 nm.
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Citations
Excessive activity of cathepsin K is associated with cartilage defects in a zebrafish model of mucolipidosis II.
Dis Models Mech . 2011 Nov 01 ; 5(2) 177 | DOI : 10.1242/dmm.008219
- A.C. Petrey
- et al