Example of a tube containing an Oligonucleotides with 5' Thiophosphate modification
Oligos

5' Thiophosphate - 1 modification

€78.20
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  • Cat.Number : MD-MF060-05004
  • Availability :
    In production

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Thiophosphates (also known as phosphorothioates) are chemical compounds containing one or more sulfur and oxygen atoms linked to a phosphorus atom.
Monothiophosphates have a general chemical formula : [PO3S]3- and are used in oligonucleotides to increase the backbone resistance against nuclease digestion.

These analogs of phosphate with the substitution of a non-bridging oxygen by sulphur can be used in transcription studies, silencing…

Thiophosphates also known as Phosphorothioate bonds possess an increased resistance against nucleases due to the substitution of a non-bridging oxygen by sulphur.

Specifications

Chemistry
Molecular Mass/ Weight
  • 96,04
Modification
Modification Position
  • 5'
Storage & stability
Resuspension condition
  • - Spin the tube briefly to collect the pellet in the bottom of the tube - Add an appropriate volume of recommended buffer (refer to technical data sheet) - Allow the tube to stand a few minutes - Vortex the tube for 15 seconds
Storage Conditions
  • Dried Oligonucleotides are stable for 18 months at ambiant temperature. Oligonucleotides in solutions are stable for 24 months at -20°C. (Tolerance -20°C± 5°C. ) For more information please refer to the Reconstitution-Storage-Stability page
Activity
Usage
  • Research use
Codes
Code Nacres
  • NA.51

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