2' O-MOE RNA Base Phosphorothioate Linkage - 1 base with PTO Linkage

2’-O-(2-Methoxyethyl)- oligoribonucleotides or 2’-O-MOE have an analogue chemical structure to RNA excepted that a methoxy-ethyl residue is attached at the 2’-O-position.
The chemical group at this position confers to the oligo backbone a highest nuclease resistance and a better binding affinity compared to the classical RNA molecule making it a useful tool for antisens applications.
At Eurogentec we use 2’ -MOE-A, 2’ -MOE-5Me-C, 2’ -MOE-G and 2’ -MOE-5-Me-U as 2’O-MOE bases.
Benefits:
- Nuclease resistant
- High binding affinity
- Reduced unspecific protein binding
- Superior half life in tissues
Phosphorothioate bonds possess an increased resistance against nucleases due to the substitution of a non-bridging oxygen by sulphur.

Length: From 5 to 139 bases
Synthesis scale: 40 nmol - 200 nmol - 1000nmol - 2.5 µmol - 5µmol - 10 µmol - 20 µmol (Larger quantities available on request)
Modifications: More than 300 modifications available
Purifications: SePOP desalting, HPLC, PAGE, Dual HPLC
Quality Control: MALDI-TOF MS
Format: Dried. other formats on option
Packaging: 2 mL tube, 96-well or 384-well plates. Higher scales from 2.5 µmol may be delivered in 50mL tubes.

Specifications

Downloads